Wang Fengliang, Wang Shui, Ling Lijun, Shen Enchao, Liu Xiaoan Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu
ã€Abstract】 Objective: To compare serum anti-tartaric acid phosphonate enzyme Tracp5b), carbohydrate antigen-153 (cA-153) and carcinoembryonic antigen (cEA) in the diagnosis of breast cancer bone metastasis and to evaluate the therapeutic effect of bisphosphonate Shen's clinical significance. Methods: The serum Tracp 5b, CA-153 and CEA levels of 18 healthy women, 26 patients with bone metastatic breast cancer and 32 patients with bone metastatic breast cancer were detected by enzyme-linked immunosorbent assay (El ISA) and electrochemiluminescence Detection of serum Tracp 5b, CA-153 and CEA levels in 19 patients with breast cancer bone metastases after oral administration of bisphosphonate bone phosphonate (clodronate) for 3 months. Results: The level of serum Tracp 5b in breast cancer bone metastasis group was significantly higher than that in non-bone metastasis group and healthy control group, the difference was statistically significant, P <0.05; the sensitivity of serum Tracp5b in the diagnosis of breast cancer bone metastasis was 78. 13, specificity is 86.36; CA_153 sensitivity is 37.5O, specificity is 77.27; CEA sensitivity is 21.88, specificity is 84. O9; Tracp 5b has higher sensitivity than CA-153 and CEA, the difference is statistically significant, P <0.05. In the bone metastasis group, Tracp5b levels decreased significantly after 3 months of bisphosphonate treatment, the difference was statistically significant (P <0.05), but CA_153 and CEA did not decrease significantly, the difference was not statistically significant, P> 0.05. Conclusion: Tracp5b is more sensitive in the diagnosis of breast cancer bone metastasis than CA-153 and CEA, and it can be used as one of the serum markers for the diagnosis of breast cancer bone metastasis and the evaluation of the efficacy of bisphosphonate therapy.
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