Influenza is an acute respiratory infection caused by influenza virus. The three major influenza epidemics in the 20th century included the Spanish influenza epidemic in 1918, the Asian influenza in 1957, and the influenza A H1N1 influenza in Hong Kong in 1968, which killed more than 40 million people and was accompanied by huge economic losses. After the 21st century, the outbreaks of SARS, H1N1, and bird flu have also caused widespread panic and economic losses worldwide. However, the current diagnosis of influenza requires a comprehensive analysis of epidemiological history, clinical symptoms, and etiological examination. It takes a very long time and cannot meet the needs of rapid diagnosis.
Peking University researchers quickly and easily collected exhaled breath condensate through an independently developed exhaled breath condensate collection device (the relevant achievements have been authorized by the national invention patent), and developed a set of rapid detection of influenza using silicon nanowire field effect transistor biosensing technology New method. The research results show that this method can achieve the goal of rapid diagnosis of influenza in just a few minutes. The study also found that enriching the virus with magnetic beads can enhance the detection signal and further reduce the detection limit. Compared with traditional gold labeling methods such as virus isolation, cultivation, and quantitative gene amplification in laboratory, the time of silicon nanowire sensor in flu diagnosis is shortened from days, hours to minutes, and the detection sensitivity is high (about 30 viruses Per microliter), research shows that silicon nanowire biosensors can be directly used for clinical influenza diagnosis after being calibrated by virus standards and negative controls (reliability rate reaches 90%). The industrialization of related technologies is expected to revolutionize current influenza diagnosis and screening Technical means.
As co-corresponding authors, Researchers Yao Maosheng and Guo Xuefeng are young talents introduced by Peking University's "Hundred Talents" project. Professor Zhu Tong is a distinguished professor of the Yangtze River and director of the Peking University Environmental and Health Research Center. The co-first authors of the paper are Shen Fangxia, a PhD student in the School of Environmental Science and Engineering, Peking University, and Wang Jindong, a PhD student in the School of Chemistry and Molecular Engineering, Peking University. Other co-authors include Xu Zhenqiang, Wu Yan, and Chen Qi Li Xiaoguang, Xu Jie, Chief Physician, Department of Infectious Diseases, Peking University Third Hospital and Professor Li Lidong, School of Materials Science and Engineering, University of Science and Technology Beijing. The main funding for this research comes from 863 key topics and the State Key Joint Laboratory of Environmental Simulation and Pollution Control.
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