The key technology of high-energy phosphoryl compound passed identification Recently, the project of “Key Technology Research and Application Based on High-Energy Phosphorus Compound†chaired by Professor Ying Hanjie of National Biochemical Engineering Technology Research Center of Nanjing University of Technology passed the appraisal of the project hosted by Jiangsu Provincial Department of Education . This research is of great significance for promoting the development of China's nucleoside pharmaceutical industry. The researchers used in-situ regeneration of energy, chemical substances to regulate metabolic flux and improve energy self-coupling efficiency, using yeast whole cell catalytic technology to efficiently prepare nucleoside triphosphate, fructose-1,6-diphosphate and their metal salts Derivatives and other high-energy phosphoryl compounds. They used a self-designed continuous ion exchange system to separate the above-mentioned high-energy phosphoryl compounds. For the first time, the crystallization method under the synergistic effect of alcohol precipitation and salt precipitation was used to crystallize the above compounds, and found a new compound-fructose-1,6-di Strontium phosphate can be used to treat and prevent osteoporosis and sexual dysfunction. Many new products of high-energy phosphoryl compounds developed by this project will inject new vitality into the research and development of biochemical and fine chemicals, and will drive the development of the entire high-energy phosphoryl compounds in China. The achievement has been industrialized in the cooperation unit. The output value in the past three years is 520 million yuan, and the newly-increased profits and taxes are 130 million yuan. The new compound-fructose-1,6-diphosphate strontium salt has cooperated with Nanjing Oxicon Pharmaceutical Group Approval of new drugs.
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